Matrion Product Specifications

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Instructions for Use
Product Specifications


Matrion is one of the first decellularized placental grafts to utilize all three layers of the placental membrane, including the trophoblast layer.
Processed with Matracell® decellularization technology, it is the first naturally intact, full-thickness, decellularized placental membrane.
  • Handling: Matrion’s inclusion of the amnion, chorion and trophoblast layers results in a graft that is up to four times thicker than the Amniotic and Chorionic membranes.1
  • Convenience: No need to rehydrate, thaw or otherwise prepare prior to application.
  • Safety: Up to four times thicker than traditional bilayer grafts, Matrion provides a more substantial barrier, preventing fluid loss as well as bacterial ingress.2
  • Sterility: Sterilized to a Sterility Assurance Level (SAL) of 10-6, medical device grade sterility.3
  • Growth Factor Retention: Matrion retains more endogenous growth factors than other placental membranes that lack the full trophoblast layer.4  Analyses have demonstrated that the trophoblast layer accounts for more than 50% of the total amount of key biological factors in placental tissue.5
Clinical Application
As a barrier membrane for chronic wounds, including diabetic foot ulcers, venous stasis ulcers, pressure ulcers and dehisced surgical wounds.
Room Temperature Description Sizing
PAC64 Solid Sheet 8 x 8 cm
PAC64M Fenestrated Sheet 8 x 8 cm
PAC25 Solid Sheet 5 x 5 cm
PAC25M Fenestrated Sheet 5 x 5 cm
PAC12 Solid Sheet 3 x 4 cm
PAC12M Fenestrated Sheet 3 x 4 cm
PAC06 Solid Sheet 2 x 3 cm
PAC06M Fenestrated Sheet 2 x 3 cm
PAC20mm Solid Sheet 20 mm disk
  1. Matrion Technical Monograph, 68-40-377.00
  2. Verbruggen SW, Oyen ML Phillips AT, Nowlan NC. Function and failure of fetal membrane: Modelling the mechanics of the chorion and amnion. PLoS One. 2017; 12(3): e0171588.
  3. 10-008, Process, PQ, Method 2B Terminal Sterilization Validation for the Devitalized Dermis Allografts Family
  4. Qin, X., Chen, S., Aschenbach, L., Chen, J., inventor; LifeNet Health, assignee. Decellularized placental membrane and methods of preparing and use thereof. WO/2017/112934.
  5. LifeNet Health. TR-004-2020 Characterization of the Amnion, Chorion, and Trophoblast Layers of Decellularized and Freeze-Dried Placental Membrane. 2020.